Clinical effectiveness of bedaquilin and delamanid treatment of children and adolescents with drug-­resistant tuberculosis

Objective — to study the clinical effectiveness of chemotherapy using bedaquiline (Bdq) and delamanid (Dlm) in children adolescents with multidrug-resistant (MDR) extensive drug resistant (XDR) pulmonary tuberculosis lungs (TBL).
 Materials methods. A retrospective cohort analysis medical records 40 patients (TB) MDR/XDR was conducted order Bdq Dlm. Among were 25 (62.5 %) aged 0 14 years 15 (37.5 teenagers 17; there 18 (47.5 boys, 22 (52.5 girls. The divided into two groups: first group second teenagers. Microbiological research included: detection Mycobacterium (MTB) sputum by smear microscopy, sowing material on Levenstein—Jensen medium, typing isolated mycobacteria BACTEC MGIT 960, determination susceptibility test strains MTB antituberculosis drugs (ATBDs) first- second-line, as well molecular genetic sputum, particular GeneXpert MTB/RIF/Ultra linear probe analysis. All received an individualized treatment regimen depending resistance ATBDs or at source infection.
 Results discussion. examined (25), who prescribed Dlm, almost half (44.0 from 4 years, 12.0 % 5 8 44.0 9 years. Patients 17 (46.7 prevailed among (15). MDR/RIF-TB diagnosed 10 (40.0%), XDR-TB determined 3 (12.0 risk MDR-TB (RMDR-TB) 12 (48.0 a new At same time, 1.7 times more often, 2.8 often RMDR-TB 3.3 less compared children.The primary tuberculous complex found children, TB damage lung bone (16.0 %), intrathoracic lymph nodes central nervous system 2 (8.0 infiltrative %). observed 7.5 disseminated form than children.All didn’t excretion after months However, non-bacterial all achieved within (CT). Significant positive X-ray dynamics 23 (92.0 (80.0 during CT. Lung changes remained (20.0 treatment. both resolution infiltration, densification focies formation fibrosis confirmed radiologically end course treatment.
 Conclusions. 21 (84.0%) (66.7 cured use Treatment completed (33.3 vs. 16.0 %, p < 0.05). success occurrence established adolescents. In addition, 84.0 73.3 ended small residual changes.